What is the EGFR Protein?
The EGFR encoded protein has distinct characteristics that determine the function of normal functionality of cell transduction in response to Cyclin D and other cell cycle regulators [1]. These attributes have been described through its interaction network, post-translation modification, homology, phylogenetic and structural protein domains. As shown bellow, there are multiple EGFR mutations that affect the structure and function of this transmembrane protein.
EGFR is associated with lung adenocarcinoma, which is a transmembrane receptor that affects transcription factors and cell cycle progression. Growth factor signaling can change according to external stimuli and even diet [2]. In LADC, the protein sequence of EGFR is important for understanding biological data. Bellow is a FASTA file containing EGFR's protein sequence.
protein.fa |
References
1.) Sara Barberán,1 José M. Martín-Durán, Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea, 2016. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914847/
2.) Asymmetric dimerization of EGFR kinase domains. Retrieved From: https://www.nature.com/scitable/content/asymmetric-dimerization-of-egfr-kinase-domains-14622319/
2.) Asymmetric dimerization of EGFR kinase domains. Retrieved From: https://www.nature.com/scitable/content/asymmetric-dimerization-of-egfr-kinase-domains-14622319/