What is the EGFR Gene?
DNA sequences are compacted into chromosomes during the start of mitosis, or cell replication. The figure shows a useful way of representing where the EGFR gene resides in the human genome. However, changes to certain sequences can illustrate the role genes have in cellular function.
As shown on the right, the EGFR resides on Chromosome 7 and consists of 28 exons, which encode more than a dozen isoforms [1]. With this in mind, what sequences are sufficient for correct cellular functions? As shown on the right, the Tyrosine Kinase domain can be encoded by exons 18-24. The gene ontology, expression and chemical genomics pages contain information about the TK domain its behavior in EGFR signalling.
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The Tyrosine kinase contain most of the driver mutations in LADC, which contribute to cell cycle metastasis and proliferation in cancer tissue [2]. This gene is studied from a variety of different aspects as outlined in this website, including Gene Ontology, Transcriptonomics and Chemical Genomics. Studying the EGFR gene in this context could yield information about its relationship to Lung Adenocarcinoma.
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References
1.) Martin, Kelly, et al., Epidermal Growth Factor Receptor-Targeted Agents for Lung Cancer (2006). Retrieved from: https://www.researchgate.net/publication/7046863_Epidermal_Growth_Factor_Receptor-Targeted_Agents_for_Lung_Cancer
2.) Yingying Tian, et. al, (2018). Different subtypes of EGFR exon19 mutation can affect prognosis of patients with non-small cell lung adenocarcinoma [Pubmed Article]. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211626/pdf/pone.0201682.pdf
3.) Nele Van Der Steen, et al., (2018). Resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer [Pubmed Article]. Retrieved from: https://cdrjournal.com/article/view/2823
2.) Yingying Tian, et. al, (2018). Different subtypes of EGFR exon19 mutation can affect prognosis of patients with non-small cell lung adenocarcinoma [Pubmed Article]. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211626/pdf/pone.0201682.pdf
3.) Nele Van Der Steen, et al., (2018). Resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer [Pubmed Article]. Retrieved from: https://cdrjournal.com/article/view/2823